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ZJRMS 2010, 12(4): 11-16 Back to browse issues page
Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat
Fatemeh Arbabi-Kalati , Mehran Mesgari-Abbasi, Narjes Akbari
, f_kalati@yahoo.com
Abstract:   (11935 Views)

  Background : Oral cancer is one of the ten most frequent cancers worldwide. Reactive oxygen species (ROS), may play a key role in human cancer development. Inflammation occurs in cancers and increases oxidative stress agent COX2 over expression in oral premalignant lesions. Several studies showed COX2 inhibitors con improve antioxidant system. The aim of this study is the evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat.

  m aterials and Method : Fifty male Sprague Dawley adult 3-3.5 months' old rats were used as animal model in this study. The tongue SCC was induced by a daily administration of 30 ppm 4-nitroquinoline 1-oxide (4-NQO), in drinking water, for 8 months. The rats in case groups received dietary or topical CCB. CCB powder was added to powdered basal diet and e ach rat received CCB with daily food. Adhesive Gels were prepared by mixing the base plasty with oral paste including two different dose of CCB. These groups include: group A» 30 ppm 4-NQO treatment group B» 30 ppm 4-NQO+dietary CCB treatment group C» 30 ppm 4-NQO+topical low dose CCB treatment group D» 30 ppm 4NQO+high dose topical CCB treatment and group E» dietary CCB as control+water.

  Results : Statistical analysis showed significant differens between groups in total antioxidant, hemoglobin and nutrophilic count.  

Conclusion : Topical CCB can use as adjuvant treatment for premalignant lesions

Keywords: Oral cancer, celecoxib, antioxidant
Full-Text [PDF 212 kb]   (2475 Downloads)    
Type of Study: Research |
* Corresponding Author Address: Assistant Professor of Oral Medicine, School of Dentistry, Zahedan University of Medical Sciences and Health Services, Zahedan, Iran.
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Arbabi-Kalati F, Mesgari-Abbasi M, Akbari N. Evaluation the effect of topical and systemic celecoxib on serum antioxidant in induction of tongue neoplasm in rat. ZJRMS. 2010; 12 (4) :11-16
URL: http://zjrms.ir/article-1-753-en.html


Volume 12, Issue 4 (12-2010) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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