Nonalcoholic fatty liver disease (NAFLD) describes a common clinico-pathological condition characterized by significant lipid deposition in the hepatocytes of liver parenchyma in patient without a history of excessive alcohol ingestion. The objective of this study was to assess the clinical and paraclinical features and risk factors for NAFLD patients in comparison to healthy populance.
Materials and methods:The study case control was undertaken on patients with NAFLD in East Azerbaijan province. 102 patients with Ultrasonography proved steatos-hepatitis and 102 controls (normal liver in ultrasound study) were enrolled in the current study. Liver function tests, lipid profile and glucose, Body mass index (BMI) and waist circumference were calculated in all subjects. All statistical analyses were performed by using chi-square and t tests and a logistic regression model.
Result:This study consist of 102 patients (56 men and 46 women) and 102 controls (43 men and59 women) (P=0.089) with mean age of 42.53
10.70 years for patients and 45.46 13.51 years for controls (P=0.069).
The mean of BMI were 30.51 4.69 in patients group and 26.48 4.40 in control group (P< 0.0005).9.8% of patients were underweight, 41.17% were in normal range and 49.01% of patients were obese.
The central obesity was seen in 59.8% of patients group and 30.7% of controls group (P<0.05). The incidence of hypertriglyceridemia (63.7% vs. 20.2%), hypercholesterolemia (20.2% vs. 9.8%), hypertension (%47.6 vs. 10.8%), diabetes (21.4% vs 2.3%) elevated ALT (46.6% vs 0.9%)and AST (37.9% vs 2.9%) were significantly higher in the NAFLD group compared to controls (P<0.0005). Besides, hypertension, grade of BMI and hyper-triglyceridemia were independently predictors.
Conclusions:Nonalcoholic fatty liver disease has similar characteristics in our population compared to other parts of world. Hypertension, grade of BMI and hyper-triglyceridemia may be used as tips to start screening in our population.