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:: Volume 16, Issue 12 (Basic Science Issue - December 2014) ::
ZJRMS 2014, 16(12): 29-34 Back to browse issues page
The Effects of Quercetin and Retinoic acid on Skeletal System of Rat Embryos in Prenatal Period
Nahid Gohari-Behbahani , Mahmood Khaksary-Mahabady , Reza Ranjbar , Hossein Najafzadeh-Varzi , Babak Mohammadian
Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran , mkhaksary@scu.ac.ir
Abstract:   (6325 Views)
Background : Prenatal rat embryo exposure to retinoid induces some malformations in various organs, the most active and teratogenic metablolite is all-trans-retinoic acid (atRA). The teratogenic effects of some drugs can be prevented by the application of antioxidant drugs and stimulation of the maternal immune system. Also, quercetin, a naturally occurring flavonoid has excellent antioxidant properties. Therefore, in this study, the prophylactic effect of quercetin on teratogenic effects of atRA was evaluated.
Materials and Methods : In this experimental study, 40 pregnant rats were divided into 7 groups. Control group received normal saline and test groups received dimethylsulfoxide (DMSO), quercetin (75 mg/kg), quercetin (200 mg/kg), atRA (25 mg/kg), atRA (25 mg/kg) plus quercetin (75 mg/kg) and atRA (25 mg/kg) plus quercetin (200 mg/kg), intraperitoneally at 8-10th days of gestation. Fetuses were collected at 20th day of gestation and after determination of weight and length they were stained by Alizarin red-Alcian blue method.
Results : Cleft palate, exencephaly and spina bifida incidence were 30.76, 61.53 and 30.76% range in group which received only atRA. Cleft palate, exencephaly and spina bifida incidence were 11.11, 16.66 and 5.55% in group which received atRA plus quercetin (75 mg/kg). However, cleft palate, exencephaly and spina bifida incidence were 10.52, 10.52 and 0% in group which received atRA plus quercetin (200 mg/kg). The means of weight and length of fetuses from rat that received atRA plus quercetin (75 mg/kg) were significantly greater than those received only atRA.
Conclusion : It is concluded that quercetin decreased teratogenicity induced by atRA, but this subject needs more detailed evaluation.
Keywords: Retinoic acid, Quercetin, Pregnancy, Cleft palate, Teratogenicity, Fetus, Rat
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Type of Study: Research | Subject: Anatomy
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Gohari-Behbahani N, Khaksary-Mahabady M, Ranjbar R, Najafzadeh-Varzi H, Mohammadian B. The Effects of Quercetin and Retinoic acid on Skeletal System of Rat Embryos in Prenatal Period. ZJRMS. 2014; 16 (12) :29-34
URL: http://zjrms.ir/article-1-3153-en.html


Volume 16, Issue 12 (Basic Science Issue - December 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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