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ZJRMS 2014, 16(7): 31-34 Back to browse issues page
The Evaluation of Psychological Factor and Salivary Cortisol and IgA Levels in Patients with Oral Lichen Planus
Tahereh Nosratzehi, Fateme Arbabi-Kalati , Saeedeh Salimi, Elham Honarmand
, farbabi@razi.tums.ac.ir
Abstract:   (5758 Views)
Background : Oral lichen planus (OLP) is a chronic immunological disorder with unknown etiology. The aim of this study was to determine psychological factors and salivary cortisol, IgA level in patients with oral lichen planus.
Materials and Methods : In this experimental study 20 patients with OLP and healthy person were admitted to this study. Saliva samples were collected between 9-10 Am. saliva cortisol, IgA level was detected by ELIZA method. In this study, patients with anxiety and depression were measured using the SCL-90 questionnaire. Data analyzed by t-test.
Results : The mean salivary cortisol level in patients with OLP was 3.2±1.9 ng/mL and the mean saliva cortisol level in healthy person was 3.5±1.9 ng/mL. Significant difference was observed in the salivary cortisol levels in the 2 study groups (p=0.04). The mean salivary IgA level in patients with OLP was 0.69±0.29 ng/mL and the mean saliva IgA level in healthy person was 0.9±0.43 ng/mL but no significant difference was observed in the salivary cortisol levels in the 2 study groups. Results showed that anxiety levels in patients with oral lichen planus were slightly higher than controls but there was no significant difference between healthy subjects.
Conclusion : Finding revealed the mean salivary cortisol level in patient with OLP less than healthy persons. Significant difference was observed in the salivary cortisol levels in the 2 study groups. Based on the t-student test, no significant difference was observed in the salivary IgA levels in the 2 study groups. Anxiety levels in patients with oral lichen planus were slightly higher than controls.
Keywords: Cortisol, Oral lichen planus, Stress
Full-Text [PDF 72 kb]   (1388 Downloads)    
Type of Study: Research |
* Corresponding Author Address: Department of Oral Medicine, Genetics of Non-Communicable Disease Research Center, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan, Iran
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Nosratzehi T, Arbabi-Kalati F, Salimi S, Honarmand E. The Evaluation of Psychological Factor and Salivary Cortisol and IgA Levels in Patients with Oral Lichen Planus. ZJRMS. 2014; 16 (7) :31-34
URL: http://zjrms.ir/article-1-3116-en.html


Volume 16, Issue 7 (Clinical Science Issue - July 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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