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:: Volume 16, Issue 12 (Basic Science Issue - December 2014) ::
ZJRMS 2014, 16(12): 51-54 Back to browse issues page
Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran
Milad Mohammadoo-Khorasani , Saeedeh Salimi , Ehsan Tabatabai , Mahnaz Sandoughi , Zahra Zakeri
Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran , sasalimi@yahoo.com
Abstract:   (4167 Views)
Background : Systemic lupus erythematosus (SLE) is an autoimmune disease with unknown etiology. Interleukin-1 receptor antagonist (IL-1Ra) is naturally occurring cytokine that inhibits interleukin-1 (IL-1) activity by binding to the IL-1 receptors without signal transduction. The aim of this study was to investigate the association between IL-1Ra gene 86bp VNTR polymorphism and systemic lupus erythematosus in the South- East of Iran.
Materials and Methods :
 In this case control study, genetic polymorphism was analyzed in 163 SLE patients and 183 healthy controls. Genotyping of IL-1Ra VNTR polymorphism was determined by gel electrophoresis after PCR amplification.
Results :
 IL-1Ra VNTR alleles have different copies of 86bp tandem repeats: allele 1(four repeats), allele 2 (two repeats), allele 3 (five repeats), allele 4 (three repeats) and allele 5 (six repeats). We found an increased frequency of IL-1Ra allele 4 and 1/4 genotype in SLE patients compared to healthy controls (p=0.001 and p=0.002 respectively). Whereas, the frequency of IL-1Ra allele 3 was higher in controls than SLE patients (p=0.01). There was no any association between the IL-1Ra allele 2 and SLE. We did not observe any association between IL-1Ra polymorphism and SLE manifestations.
Conclusion : We concluded that IL-1Ra allele 4 was involved in the pathogenesis of SLE. However, there was no association between the IL-1Ra allele 2 and SLE in South East of Iran.
Keywords: Systemic lupus erythematosus, Interleukin-1 receptor antagonist, VNTR, Polymorphism
Full-Text [PDF 137 kb]   (1327 Downloads)    
Type of Study: Research | Subject: Genetics and Molecular Biology
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Mohammadoo-Khorasani M, Salimi S, Tabatabai E, Sandoughi M, Zakeri Z. Association of Interleukin-1 Receptor Antagonist Gene 86bp VNTR Polymorphism with Systemic Lupus Erythematosus in South East of Iran. ZJRMS. 2014; 16 (12) :51-54
URL: http://zjrms.ir/article-1-3075-en.html


Volume 16, Issue 12 (Basic Science Issue - December 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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