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:: Volume 16, Issue 10 (Basic Science Issue - October 2014) ::
ZJRMS 2014, 16(10): 60-64 Back to browse issues page
Phytochemical Analysis, Antibacterial Activity of Marrubium vulgare L against Staphylococcus aureus in vitro
Mohammad Bokaeian , Elham Saboori , Saeide Saeidi , Abbas Ali Niazi , Negar Amini-Borojeni , Hamde Khaje , Saphora Bazi
Department of Biology, Faculty of Science, Science and Research Branch, Islamic Azad University, Kerman, Iran , s.saeedi12@yahoo.com
Abstract:   (9538 Views)
Background : Herbal medicines are the major remedy in traditional medical systems and made a great contribution in maintaining human health and in preventing many infectious diseases. The present study was carried out to determine the potential antibacterial effect of ethanol extracts and essential oil of Marrubium vulgare L. against Staphylococcus aureus which is antibiotic resistant.
Materials and Methods : All 17 strains of S. aureus isolated from nose and throat sample from 160 healthy subjects, hospital staffs and inpatient in the city of Zabol (Amir Al-Momenin hospital, Zabol, south-eastern Iran) were screened during years 2010-2011. In this study, the essential oil of Marrubium vulgare L. obtained by hydrodistillation was analyzed by gas chromatography coupled to mass spectrometry (GC-MS) in order to determine their chemical composition. The minimum inhibitory concentrations were investigated to characterize the antimicrobial activities of this essential oil and extract.
Results : Thirty-one components in the oil of Marrubium vulgare were identified. The results demonstrated that the major components of the essential oil were γ-Eudesmol (11%), Germacrene (10%), D-Citronelly formate (10%), β-Citronellol (8%), Geranyl tiglate (7.1%), Geranyl formate (6.02%). The least MIC value of extract M. vulgare was 2.5 mg/mL and the highest MIC value of essential oil M. vulgare was 2.5 mg/mL.
Conclusion : This investigation showed that the M. vulgare essential oil and extract has a potent antimicrobial activity against S. aureus. The present studies confirm the use of this essential oil and extract as antibacterial agent. Further research is required to evaluate the practical values of therapeutic applications.
Keywords: Phytochemical analysis Antibacterial activity, Marrubium vulgare L
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Type of Study: Research | Subject: Microbiology
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Bokaeian M, Saboori E, Saeidi S, Niazi A A, Amini-Borojeni N, Khaje H et al . Phytochemical Analysis, Antibacterial Activity of Marrubium vulgare L against Staphylococcus aureus in vitro. ZJRMS. 2014; 16 (10) :60-64
URL: http://zjrms.ir/article-1-3051-en.html


Volume 16, Issue 10 (Basic Science Issue - October 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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