[Home ]     [ فارسی ]  
:: Main Online Submission Archive Current Issue In Press ::
:: Volume 17, Number 2 (Basic Science Issue - February 2015) ::
Back to browse issues page ZJRMS 2015, 17(2): 60-62
Effect of Acute and Chronic Administration of Methimazole on Morphine Withdrawal Signs in Adult Male Mice
Mahnaz Kesmati , Khadijeh Gholami, S. Reza Kazeminejad
Department of Biology, Faculty of Sciences, Shahid Chamran University, Ahvaz, Iran , m.kesmati@scu.ac.ir
Abstract:   (3354 Views)
Background : Opioid receptors change in CNS by anti thyroid hormones drugs. In this study effect of acute and chronic methimazole (aMTZ and cMTZ) administration on morphine withdrawal were investigated.
Materials and Methods :
 In this experimental study adult male mice divided into control and experimental groups receiving aMTZ or cMTZ. All groups were addicted to morphine and morphine withdrawal was induced by naloxone and jumping, rearing and climbing signs were evaluated.
Results :
Acute MTZ and chronic MTZ increased the climbing and jumping (p< 0.01, p< 0.001). cMTZ was more potent than the acute one.
Conclusion :
MTZ probably influences an opioid abstinence directly and/or indirectly through decrement of thyroid hormones.
Keywords: MTZ, Morphine withdrawal syndrome, Opioid receptors
Full-Text [PDF 126 kb]   (1429 Downloads)    
Type of Study: Short Communication | Subject: Physiology
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Kesmati M, Gholami K, Kazeminejad S R. Effect of Acute and Chronic Administration of Methimazole on Morphine Withdrawal Signs in Adult Male Mice. ZJRMS. 2015; 17 (2) :60-62
URL: http://zjrms.ir/article-1-3003-en.html
Back to browse issues page Volume 17, Number 2 (Basic Science Issue - February 2015)
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.066 seconds with 783 queries by yektaweb 3300