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:: Volume 16, Issue 10 (Basic Science Issue - October 2014) ::
ZJRMS 2014, 16(10): 18-22 Back to browse issues page
The Effect of Chelidonium majus Extract on the Lipid Profile and Activity of Pituitary-Gonadal Axis in Hypercholesterolemic Rats
Ali Zarei , Saeed Changizi-Ashtiyani , Azam Rezaei , Hassan Sheidaee , Fatemeh Nabiyoni
Department of Physiology, Arak University of Medical Sciences, Arak, Iran , ashtiyani@sums.ac.ir
Abstract:   (4599 Views)
Background : Over the past centuries, global population has increased at different rates and so has been the case with cardiovascular diseases. Therefore, given the importance of population and cholesterol control, the purpose of this study is to investigate the effect of Chelidonium majus (C. majus) aerial parts extract on the lipid profile and prolactin levels and the activity of pituitary-gonadal axis in hypercholesterolemic rats.
Materials and Methods : In this experimental study, 35 Wistar rats were selected and categorized into 5 groups. The control group had ordinary diet, the model group had high-fat diet, and experimental groups consisted of hypercholesterolemic rats that respectively received minimal dosages of 100, 200 and 300 mg/kg of C. majus extract. After 21 days, blood samples were taken and the factors of interest were measured. Then, the gathered data were analyzed using SPSS-11.5.
Results : The amount of triglyceride and cholesterol were increased in the model group compared to the control group whereas the same items were decreased in the experimental group. C. majus extract also decreased testosterone and increased prolactin and gonadotropins.
Conclusion : In this study, C. majus extract resulted in decreased fat and testosterone levels as well as increased prolactin level however, since many sources have informed of the toxicity of this plant, cautious use of the plant is advised.
Keywords: Chelidonium majus, Prolactin, Testosterone, Cholesterol, Gonadotropins
Full-Text [PDF 212 kb]   (1992 Downloads)    
Type of Study: Research | Subject: Endocrinology
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Zarei A, Changizi-Ashtiyani S, Rezaei A, Sheidaee H, Nabiyoni F. The Effect of Chelidonium majus Extract on the Lipid Profile and Activity of Pituitary-Gonadal Axis in Hypercholesterolemic Rats. ZJRMS. 2014; 16 (10) :18-22
URL: http://zjrms.ir/article-1-2975-en.html


Volume 16, Issue 10 (Basic Science Issue - October 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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