:: Volume 16, Issue 10 (Basic Science Issue - October 2014) ::
ZJRMS 2014, 16(10): 42-46 Back to browse issues page
In-Vitro Antibacterial Properties of Sage (Salvia officinalis) Ethanol Extract against Multidrug Resistant Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Klebsiella pneumoniae
Elham Mosafa , Sima Yahyaabadi, Monir Doudi
Department of Microbiology, Islamic Azad University, Falavarjan Branch, Isfahan, Iran , elham.mosafa@yahoo.com
Abstract:   (14670 Views)
Background : Due to excessive consumption of synthetic drugs, drug resistance rate of pathogenic bacteria is increasing and the need to find new compounds is necessary. The aim of this study was to investigate the antibacterial effect of ethanol extract of, sage to the four species of common pathogenic bacteria resistant to multiple drugs in vitro such as: Staphylococcus aureus (50 strains), Escherichia coli (50 strains), Pseudomonas aeruginosa (50 strains) and Klebsiella pneumonia (50 strains).
Materials and Methods : In this experimental study, antibacterial effect of ethanol extract of sage plants on the development of multi-drug resistant bacteria was performed by well diffusion at concentrations of 50, 400, 100 mg/mLand microdilution method.
Results : Ethanol extracts of sage in well diffusion method showed significant inhibitory effect on the growth of isolated bacteria. The results indicate the inhibitory effects of ethanol extract of sage with MIC (Minimum Inhibitory Concentration)=18.75 mg/mL for S. aureus, MIC=26.56 mg/mL for E. coli, MIC=33.75 mg/mL for P. aeruginosa and with MIC=31.25 mg/mL for K. pneumoniae.
Conclusion : In relation with the antibacterial effect of ethanol extracts of Sage on the multi-drug resistant bacteria the use of herbs as an alternative to antibiotics after pharmacological studies, for treatment recommended.
Keywords: Salvia officinalis, In-vitro, Drug resistance
Full-Text [PDF 127 kb]   (2349 Downloads)    
Type of Study: Research | Subject: Microbiology

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Volume 16, Issue 10 (Basic Science Issue - October 2014) Back to browse issues page