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:: Volume 16, Issue 11 (Clinical Science Issue - November 2014) ::
ZJRMS 2014, 16(11): 50-51 Back to browse issues page
Acute Lymphoblastic Leukemia in Two Patients with β-Thalassemia Major
Majid Naderi , Ebrahim Miri-Moghaddam , Shaban Alizadeh , Akbar Dorgalaleh , Shadi Tabibian
Department of Genetics, Genetics of Non-Communicable Disease Research Centre, Zahedan University of Medical Sciences, Zahedan, Iran , hematology.1390@yahoo.com
Abstract:   (3656 Views)
Occurrence of leukemia in thalassemia major is a rare presentation. Here we report two cases of thalassemic patients, developing acute lymphoblastic leukemia. The genetic analysis revealed that, female and male patients were homozygous for IVSI-6 and IVSI-5, respectively. Two years ago the female patient presented by a high leukocyte count (154,000 µL) and male one also presented by 80,000 WBC/µL count 1 year ago. Microscopic examination of both patients revealed lymphoblasts that morphologically accommodate with ALL-L1 that were confirmed by photocytometry.
Keywords: Thalassemia major, Leukemia, Transfusion
Full-Text [PDF 155 kb]   (1323 Downloads)    
Type of Study: Case Report | Subject: Oncology
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Naderi M, Miri-Moghaddam E, Alizadeh S, Dorgalaleh A, Tabibian S. Acute Lymphoblastic Leukemia in Two Patients with β-Thalassemia Major. ZJRMS. 2014; 16 (11) :50-51
URL: http://zjrms.ir/article-1-2969-en.html


Volume 16, Issue 11 (Clinical Science Issue - November 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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