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:: Volume 16, Issue 12 (Basic Science Issue - December 2014) ::
ZJRMS 2014, 16(12): 1-7 Back to browse issues page
Evidence of Oxidative Damage in Paraquat Toxicity
Akram Ranjbar
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Hamadan University ‎of Medical Sciences, Hamadan, Iran , akranjbar1389@yahoo.com
Abstract:   (7055 Views)
The herbicide paraquet (1, 1-dimethyl-4, 4-bipyridilium dichloride PQ) is a highly toxic quaternary nitrogen herbicide. Many cases of PQ acute poisoning and death have been reported over the past few decades. The mechanisms of PQ toxicity have been reported to involve the generation of reactive oxygen species (ROS) in different organs. Several studies have suggested that the mechanism of PQ toxicity is associated with a redo cyclic reaction, which generates superoxide anion, singlet oxygen and other free radicals, leading to cellular NADPH depletion and lipid per oxidation of cell membranes. Then PQ poisoning is directed towards the use of antioxidants. There are several reports about oxidative stress in acute and chronic exposures to PQ. In this respect, there are several in vitro and in vivo but few clinical studies about mechanism underlying these effects. Bibliographic databases were searched for the years 1960-2013 and resulted in 378 articles. After elimination of duplicates or irrelevant papers, 70 papers were included and reviewed. Results indicated that the status of PQ toxicity and treating the toxic effects produced by PQ is presented. Nonetheless, it is reasonable for the scientific community to provide an expert review and evaluation of this herbicide and their toxic potential to produce disorders in brain, liver, kidney and lung in living organisms.
Keywords: Paraquat, Oxidative stress, Antioxidants, Reactive oxygen species, Pesticides
Full-Text [PDF 160 kb]   (2209 Downloads)    
Type of Study: Review Article | Subject: Toxicology
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Ranjbar A. Evidence of Oxidative Damage in Paraquat Toxicity. ZJRMS. 2014; 16 (12) :1-7
URL: http://zjrms.ir/article-1-2934-en.html


Volume 16, Issue 12 (Basic Science Issue - December 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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