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:: Volume 17, Issue 1 (Clinical Science Issue - January 2015) ::
ZJRMS 2015, 17(1): 43-46 Back to browse issues page
Retrospective, Single Center Study of Clinical, Paraclinical and Natural Course of Infantile-Onset Pompe Disease
Noormohammad Noori , Ghasem Miri-Aliabad , Ali Khajeh
Department of Pediatrics, Children and Adolescent Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran , gh_miri@yahoo.com
Abstract:   (6396 Views)
Background : Infantile-onset Pompe disease is a rare genetic and lethal disorder which is caused by the lack of acid alpha-glucosidase activity (GAA). The aim of our study was to identify the demographic and clinical characteristics, and natural history of these patients.
Materials and Methods : In this retrospective study, clinical file of 15 patients diagnosed with infantile-onset Pompe disease whose symptoms started before the age of 12 months were studied. Diagnosis was based on clinical history, physical examination and diagnostic parameters in chest X-ray, echocardiogram, electrocardiogram and biochemical tests after rule out the other metabolic and neuromuscular disorders.
Results : Sixty percent of the patients were male and 40% were female. The mean age at the onset of symptoms was 78 days (range: 3-150 days). Most frequent clinical and paraclinical symptoms were cardiomegaly, hypotonia, hyporeflexia, macroglossia, failure to thrive, hepatomegaly, and feeding problems, respectively. The mean age at the time of death was 5.96 months (range: 4-8 months), and all patients died before one year of age. Muscle enzymes including AST, ALT, LDH, and CPK were elevated in all patients. Due to the lack of availability, enzyme replacement therapy was not possible for any patient.
Conclusion : The study showed that despite the supportive measures and no specific treatment, the clinical course is not significantly different with similar studies and the overall prognosis of this form of disease is very poor and disappointing.
Keywords: Infantile-Onset Pompe Disease, Cardiomegaly, Cardiomyopathy, Hypotonia
Full-Text [PDF 382 kb]   (1664 Downloads)    
Type of Study: Case Series | Subject: Pediatrics
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Noori N, Miri-Aliabad G, Khajeh A. Retrospective, Single Center Study of Clinical, Paraclinical and Natural Course of Infantile-Onset Pompe Disease. ZJRMS. 2015; 17 (1) :43-46
URL: http://zjrms.ir/article-1-2925-en.html


Volume 17, Issue 1 (Clinical Science Issue - January 2015) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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