[صفحه اصلی ]     [ English ]  
:: صفحه اصلی ثبت نام جدید و ارسال مقاله کلیه شماره های مجله آخرین شماره مقالات زیر چاپ ::
:: دوره 17، شماره 2 - ( 12-1393 ) ::
برگشت به فهرست نشریات جلد 17 شماره 2 صفحات 31-36
Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats
چکیده:   (5429 مشاهده)
Background : We have investigated the effect of 8 weeks aerobic training (AT) and Ferula gummosis supplement (FG) on apelin and apelin receptor (APJ), nitric oxide (NO) and angiotensin converting enzyme (ACE) of hypertensive rats.
Materials and Methods : In a experimental study, 50 adult male wistar rats were classified into five groups 1- AT, 2- FG, 3- combination of aerobic training + Ferula Gummosa supplement (TFG), 4- nitro-L-arginine-methyl ester (L-NAME), 5- shame (control) groups (SH). The rats in the 1 to 4 groups received L-NAME (10 mg/kg, 6 times a week for 8 weeks). Also, the 1 and 3 groups experienced the training of 15 to 22 m/min for 25 to 64 minutes, 5 times a week for 8 weeks, whereas, the 2 and 3 groups received Ferula gummosis supplement (90 mg/kg, 6 times a week for 8 weeks). However, rats in 5 groups received NaCl solution.
Results : At protocols resulted in a significant increase in apelin and APJ as compared to control and L-NAME groups. The TFG protocols resulted in a markedly increase in apelin, APJ and significantly decrease of ACE levels as compared to L-NAME group. Chronically administration of L-NAME resulted increased, ACE, and reduced the levels of apelin, APJ and NO, as compared to control group.
Conclusion : The results in this study show that physical regular activity with and without herbal treatment induce amplification in apelin/APJ system and down-regulation blood pressure in L-NAME induced hypertension in the rat kidney tissue.
متن کامل [PDF 142 kb]   (1241 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: تربيت بدني
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

کد امنیتی را در کادر بنویسید >



XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahmoody S A A, Dabidi-Roshan V, Gharakhanlou R, Hedayati M. Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats. ZJRMS. 2015; 17 (2) :31-36
URL: http://zjrms.ir/article-1-2768-fa.html
Improvement of Kidney Apelin and Apelin Receptor in Nitro-L-Arginine-Methyl Ester Induced Rats. Zahedan Journal of Research in Medical Sciences. 1393; 17 (2) :31-36
برگشت به فهرست نشریات دوره 17، شماره 2 - ( 12-1393 )
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.048 seconds with 786 queries by yektaweb 3302