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ZJRMS 2013, 15(10): 12-15 Back to browse issues page
Bisphenol-A Induces Oxidative Damage in the Liver of Chicken Embryos
Soraya Gharibi , Parisa Sadighara , Tahereh Mohajerfar , Ramin Mazaherinezhad-Fard , Tahereh Farkhondeh
, Farkhondeh2324@gmail.com
Abstract:   (7325 Views)
Background : Oxidative stress mechanisms are involved in the embryotoxicity. The objective of this study was to assess hepatotoxicity of bisphenol-A (BPA) in chicken embryos.
Materials and Methods : Fertile eggs were randomly divided into 4 groups three experimental and one control groups, (N=15, for each group). Embryos were administered 50, 100 and 200 PPM BPA, and incubated for 48 h at 37°C with a relative humidity of 63%. The experiment was terminated on day 20 of incubation. Then, the embryos were decapitated and livers of embryos were collected for biochemical analysis. The total antioxidant capacity, malondialdehyde (MDA), glutathione (GSH), carotenoid and total protein levels were measured by spectrophotometer.
Results : The result of the present study indicated that the levels of total antioxidant in the livers of embryos exposed to 200 PPM BPA were higher than control and other groups, as well as the levels of MDA compared to control group (p<0.05). The levels of GSH, total carotenoids and total protein were higher in all groups exposed to BPA than control group (p<0.05). In addition, protein concentration in 200 PPM group was higher than of other groups (p<0.001).
Conclusion : So far, BPA may lead to induce toxic response of oxidative system in liver throughout embryonic period.
Keywords: Bisphenol A, Chicken, Embryos developmental Toxicity
Full-Text [PDF 131 kb]   (1561 Downloads)    
Type of Study: Research | Subject: Physiology
* Corresponding Author Address: Department of Environmental
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Gharibi S, Sadighara P, Mohajerfar T, Mazaherinezhad-Fard R, Farkhondeh T. Bisphenol-A Induces Oxidative Damage in the Liver of Chicken Embryos. ZJRMS. 2013; 15 (10) :12-15
URL: http://zjrms.ir/article-1-2751-en.html


Volume 15, Issue 10 (Basic Science Issue - October 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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