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:: Volume 16, Issue 2 (Basic Science Issue - February 2014) ::
ZJRMS 2014, 16(2): 15-18 Back to browse issues page
The Effect of an Angiotensin II Antagonist on Hormones of Pituitary-Gonad Axis in Adult Male Rats
S. Ebrahim Hosseini
, ebrahim.hossini@yahoo.com
Abstract:   (5818 Views)
Background : The aim of this study was to investigate the effect of valsartan, an angiotensin II antagonist, on the function of the pituitary- gonad axis.
Materials and Methods : Adult male Wistar rats (200 to 220 g) were used as experimental and control groups. The 3 experimental groups received either 100, 200, or 400 mg/kg/day valsartan in 1 ml water orally for 28 days, while a set of control group received 1 ml distilled water for the same period of time and another set received no treatment. At the end of the experimental period, blood was collected and serum was analyzed for FSH, LH, testosterone and dihydrotestosterone levels by RIA methods.
Results : There were no significant differences among FSH levels at all doses of valsartan used, while the serum LH level was decreased significantly at the maximum dose of the drug used. Serum testosterone level decreased at both the 200 and 400 mg/kg dose compared to the control, while the dihydrotestosterone level was reduced significantly at all the three dosages used.
Conclusion : According to our founding, suggested that the effects of valsartan on serum LH, testosterone and dihydrotestosterone may be mediated through angiotensin II receptor.
Keywords: Angiotensin II antagonist, LH, FSH, Testosterone, Dihydrotestosterone, Valsartan
Full-Text [PDF 101 kb]   (1920 Downloads)    
Type of Study: Research | Subject: Physiology
* Corresponding Author Address: Department of Biology, Science and Research Branch, Islamic Azad University, Fars, Iran
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Hosseini S E. The Effect of an Angiotensin II Antagonist on Hormones of Pituitary-Gonad Axis in Adult Male Rats . ZJRMS. 2014; 16 (2) :15-18
URL: http://zjrms.ir/article-1-2738-en.html

Volume 16, Issue 2 (Basic Science Issue - February 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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