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:: Volume 15, Issue 10 (Basic Science Issue - October 2013) ::
ZJRMS 2013, 15(10): 69-73 Back to browse issues page
Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy
Saeedeh Salimi , Anoosh Naghavi , Zahra Zakeri , Sima Nabizadeh , Farzaneh Farajian Mashhadi , Mahnaz Sandoughi
, mahnazsandooghi@yahoo.com
Abstract:   (6088 Views)
Background : Systemic lupus erythematosus (SLE) is a multisystem disease with unknown etiology. We hypothesized that insertion/deletion (I/D) polymorphism of angiotensin-converting enzyme (ACE) gene may influence the development and/or progression of SLE and lupus nephritis.
Materials and Methods : In a crass sectional case-control study, genomic DNA from 106 SLE patients and 103 healthy controls matched for sex, age, and ethnicity, were genotyped for the (I/D) polymorphism of ACE gene by polymerase chain reaction (PCR). Comparison of quantitative variants between two groups was assessed by student t-test and association between qualitative variables was analyzed by the chi-square or Fisher exact tests.
Results : The frequency of DD genotype in SLE patients was significantly higher than control group (25.5 % vs. 14 %), and the risk of SLE was 2.2 times greater in subjects with DD genotype than the individual by DI and II genotypes (OR, 2.2 [95% CI, 1.1 to 4.4] p=0.023). The distribution of D allele in SLE patients was significantly higher (p=0.021) compare to controls (47 and 36.4, respectively). The Risk of nephropathy in SLE patients with DD genotype was three times more than other genotypes (OR), 3 [95% CI, 1.1 to 8] p=0.027].
Conclusion : This study demonstrated that ACE DD genotype acts as a risk factor on SLE and Lupus nephropathy in an Iranian population.
Keywords: Systemic lupus erythematosus, Lupus nephropathy, Angiotensin-converting enzyme, Polymorphism, Iran
Full-Text [PDF 149 kb]   (1334 Downloads)    
Type of Study: Research | Subject: Genetics and Molecular Biology
* Corresponding Author Address: Department of Internal Medicine, Clinical Research Development Center, Faculty of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
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Salimi S, Naghavi A, Zakeri Z, Nabizadeh S, Farajian Mashhadi F, Sandoughi M. Association of DD Genotype of Insertion/Deletion Polymorphism of Angiotensin-Converting Enzyme Gene with Systemic Lupus Erythematosus and Lupus Nephropathy . ZJRMS. 2013; 15 (10) :69-73
URL: http://zjrms.ir/article-1-2733-en.html


Volume 15, Issue 10 (Basic Science Issue - October 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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