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ZJRMS 2014, 16(2): 37-41 Back to browse issues page
The Effects of Essential Oil of Galbanum on Caffeine Induced-Cleft palate in Rat Embryos
Fardokht Rashidi, Mahmood Khaksary-Mahabady , Reza Ranjbar, Hossein Najafzadeh-Varzi
, mkhaksarymahabady@yahoo.com
Abstract:   (6060 Views)
Background : Caffeine at high doses is a known rodent teratogen and induces limb malformations along with cleft palate in various strains of rats and mice. The teratogenic effects of some drugs can be prevented by the application of antioxidant drugs and stimulation of the maternal immune system. Also, there is some evidence that galbanum is antioxidant. Therefore, in this study, the prophylactic effect of galbanum on teratogenic effects of caffeine was evaluated.
Materials and Methods :
This experimental study was performed on 28 pregnant rats that were divided into four groups. Control group received normal saline and test groups received caffeine (80 mg/kg), caffeine (80 mg/kg) plus galbanum (200 mg/kg) and galbanum (200 mg/kg), intraperitonealy at 9-11th days of gestation, respectively. Fetuses were collected at 20th day of gestation and after determination of weight and length they were stained by Alizarin red - Alcian blue method.
Results : Cleft palate incidence was 33.3%, in caffeine group and decreased to 8.3% by galbanum. The mean of weight and length of fetuses from rat that received galbanum were significantly greater than those received only caffeine.
Conclusion : It is concluded that galbanum decreased cleft palate induced by caffeine but its mechanism needs more details evaluation.
Keywords: Caffeine, Galbanum, Cleft palate, Embryo, Rat
Full-Text [PDF 123 kb]   (1934 Downloads)    
Type of Study: Research | Subject: Anatomy
* Corresponding Author Address: Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran
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Rashidi F, Khaksary-Mahabady M, Ranjbar R, Najafzadeh-Varzi H. The Effects of Essential Oil of Galbanum on Caffeine Induced-Cleft palate in Rat Embryos. ZJRMS. 2014; 16 (2) :37-41
URL: http://zjrms.ir/article-1-2696-en.html

Volume 16, Issue 2 (Basic Science Issue - February 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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