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:: Volume 16, Issue 2 (Basic Science Issue - February 2014) ::
ZJRMS 2014, 16(2): 29-32 Back to browse issues page
Protective Effects of Captopril against Aflatoxin B1-Induced Hepatotoxicity in Isolated Perfused Rat Liver
Amir Moghaddam-Jafari , Mohammad Kazem Koohi , Mahmood Ghazi-Khansari , Parvin Pasalar
, moghadamjafari@gmail.com
Abstract:   (5906 Views)
Background : The liver is the major target organ for aflatoxin B1 (AFB1). Ingestion of aflatoxin causes hepatotoxicty. In this study, captopril as new agent to help the hepatotoxicity induced by aflatoxin was suggested.
Materials and Methods : The isolated perfused rat liver (IPRL) was chosen for evaluating hepatic function. Sixteen rats were divided randomly into four experimental groups: control, captopril, AFB1 and AFB1 + captopril. The level of glutathione content and lipid peroxidation, as marker of oxidative stress and lactate dehydrogenase (LDH), alanine transaminase (ALT) and aspartate transaminase (AST) activities and pH of the perfusate medium were measured.
Results : There was a significant decrease in lipid peroxidation and same increase was observed in glutathione level. Treatment with captopril also modulated the enzymes activity and pH of perfusate.
Conclusion : This study showed that captopril protects the hepatotoxicty induced by AFB1. Therefore, this drug may provide an effective new strategy to reduce of aflatoxins toxicity.
 
Keywords: Hepatotoxicity, Aflatoxins, Captopril
Full-Text [PDF 163 kb]   (1641 Downloads)    
Type of Study: Research | Subject: Pharmacology
* Corresponding Author Address: Department of Toxicology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
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Moghaddam-Jafari A, Koohi M K, Ghazi-Khansari M, Pasalar P. Protective Effects of Captopril against Aflatoxin B1-Induced Hepatotoxicity in Isolated Perfused Rat Liver. ZJRMS. 2014; 16 (2) :29-32
URL: http://zjrms.ir/article-1-2688-en.html


Volume 16, Issue 2 (Basic Science Issue - February 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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