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ZJRMS 2014, 16(6): 77-79 Back to browse issues page
The Survey of Serum Trace Element Profiles in Down's Syndrome
Leila Farzin , Fattaneh Sajadi, Leila Kupai
, LFarzin84@yahoo.com
Abstract:   (5508 Views)

Background : Immunological, endocrinological, haematological and neurological abnormalities are relatively common in people with Down's syndrome (DS). Zinc (Zn), copper (Cu), selenium (Se) and manganese (Mn) are elements that act in the maintenance of normal function of these systems. The present study aimed to evaluate the concentration of these elements on DS symptoms.
Materials and Methods : This case-control study was done from April to October 2011. Serum trace elements including Zn, Cu, Se and Mn were determined by using atomic absorption spectrometry (AAS) in 56 patients with DS and 60 healthy subjects.
Results : There was no significant difference in the values of Cu and Se between two groups (p>0.05). While, Zn and Mn levels were found to be significantly decreased in patients with DS compared to the control group (p<0.01 and p<0.001, respectively).
Conclusion : Results of this study indicate zinc and manganese deficiency in more than 60% of DS patients. Some of the problems experienced by people with DS may be due to changed level of these trace elements.

Keywords: Down\'s syndrome, Zinc, Selenium, Copper, Manganese, Atomic Absorption Spectroscopy
Full-Text [PDF 125 kb]   (1667 Downloads)    
Type of Study: Short Communication | Subject: Biochemistry
* Corresponding Author Address: Environmental Laboratory, Nuclear Science Research School, Nuclear Science & Technology Research Institute, Atomic Energy Organization of Iran, Tehran, Iran
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Farzin L, Sajadi F, Kupai L. The Survey of Serum Trace Element Profiles in Down's Syndrome. ZJRMS. 2014; 16 (6) :77-79
URL: http://zjrms.ir/article-1-2464-en.html


Volume 16, Issue 6 (Clinical Science Issue - June 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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