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:: Volume 15, Issue 10 (Basic Science Issue - October 2013) ::
ZJRMS 2013, 15(10): 59-64 Back to browse issues page
Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats
Negar Keyshams , Seyed Reza Fatemi Tabatabaei , Hossein Najafzadehvarzi , Ali Ashrafi
, najafzadeh@scu.ac.ir
Abstract:   (4810 Views)
Background : Vanadium compounds have antidiabetic, but there is no study about the antidiabetic effects f ammonium monovanadate nono-particles. In this study, antidiabetic effect of ammonium monovanadate was compared with its nonoparticles.
Materials and Methods : In this experimental and animal modeling study, 42 male Sprague Dawley rats were divided in 6 groups (each group 7 rats). Diabetes was induced by IP injection of 60 mg/kg streptozicin to five groups. One normal group and one diabetic group were kept without treatment as control groups. Other diabetic rats were treated with nonovanadate 25 mg/kg (NV25), ordinary vanadate 25 mg/kg (V25), nonovanadate 15 mg/kg (NV15) and water ordinary vanadate 25 mg/kg (WV25) groups for 10 days by gavage. Heparinized blood was collected at days 11 and 21 and centrifuged to separate plasma. Glycosylated hemoglobin, insulin, triglyceride (TG), total cholesterol (TC), HDL-c and LDL-c were measured at both time and compared between groups.
Results : All treatment except in V25 decreased glycemia, but insulin increased only in NV25 group (p<0.05). All treatment decreased TG, TC and LDL-c significantly (p<0.001).
Conclusion : Ammonium mono vanadate nonoparticle has better effects than ordinary ammonium mono vanadate on some biochemical factors in experimental diabetes.
Keywords: Ammonium mono vanadate nanoparticle, Diabetes, Rat
Full-Text [PDF 139 kb]   (1392 Downloads)    
Type of Study: Research | Subject: Pharmacology
* Corresponding Author Address: Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine, Shahid Chamran University, Ahvaz, Iran
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Keyshams N, Fatemi Tabatabaei S R, Najafzadehvarzi H, Ashrafi A. Effect of Amonium Vanadate Nano-Particles on Experimental Diabetes and Biochemical Factors in Male Spargue-Dawly Rats. ZJRMS. 2013; 15 (10) :59-64
URL: http://zjrms.ir/article-1-2447-en.html


Volume 15, Issue 10 (Basic Science Issue - October 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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