[صفحه اصلی ]   [Archive]  
:: صفحه اصلی ثبت نام جدید و ارسال مقاله کلیه شماره های مجله آخرین شماره مقالات زیر چاپ ::
:: دوره 15، شماره 10 - ( 8-1392 ) ::
جلد 15 شماره 10 صفحات 28-31 برگشت به فهرست نسخه ها
اثر 8 هفته تمرین استقامتی بر میزان فعالیت استیل-کولین‌استراز 12A در عضلات تند و کند موش‌های صحرایی
چکیده:   (5821 مشاهده)
Background : Endurance training improves the activity of G4 type acetylcholine esterase (AchE) in muscle fibres. The purpose of this study was to investigate the effects of 8 weeks of endurance training (ET) on activity of A12 type of AchE in Flexor Hallucis Longus (FHL) and Soleus (SOL) muscles of rats.
Materials and Methods : Sixteen male Wistar rats (age: 10 weeks, weight: 172.17±10.080 gr), were randomly divided in 2 groups (control N=8 and ET N=8). Training group carried out 8 weeks (5 session/week) of endurance training on animal treadmill with speed of 10 m/min for 30 min at the first week. Forty eight hours after last session of training, FHL and Sol muscles of animals were moved out under sterilized situation by cutting on postero-lateral side of hind limb. For separating AchE subunits, homogenization and electrophoresis (0.06 non-denaturaing polyacrilamide) methods were used. AchE activity was measured by Elisa kit.
Results :
Independent t-test showed that the activity of this protein significantly (p=0.017) increased in SOL muscle of ET group by 119%, but did not changed in FHL. In both groups (ET and Con), FHL muscle had significantly (ET: p=0.028 and Con p=0.01) higher basic levels of AchE activity compared to SOL muscle. This significant increase in AchE of SOL might be indicative of responsiveness of AchE of this muscle following endurance training for improving acetylcholine (Ach) cycle in neuromuscular junction.
Conclusion : Endurance training might increase the A12 type AchE activity to improve the Ach cycle as part of the adaptation of neuromuscular junction to increased level of physical activity.
متن کامل [PDF 97 kb]   (1854 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: فیزیولوژی ورزش
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Gorzi A, Rajabi H, Gharakhanlou R, Azad A. Effects of Endurance Training on A12 Acetyl Cholinesterase Activity in Fast and Slow-Twitch Skeletal Muscles of Male Wistar Rats. ZJRMS. 2013; 15 (10) :28-31
URL: http://zjrms.ir/article-1-2371-fa.html

اثر 8 هفته تمرین استقامتی بر میزان فعالیت استیل-کولین‌استراز 12A در عضلات تند و کند موش‌های صحرایی . Zahedan Journal of Research in Medical Sciences. 1392; 15 (10) :28-31

URL: http://zjrms.ir/article-1-2371-fa.html



دوره 15، شماره 10 - ( 8-1392 ) برگشت به فهرست نسخه ها
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.09 seconds with 32 queries by YEKTAWEB 3903