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ZJRMS 2013, 15(11): 24-28 Back to browse issues page
Inhibition Effects of Teucrium Polium Extract on Gout
Elnaz Saghafi, Manijeh Mianabadi , Gholamreza Hadadchi
, m.mianabadi@gu.ac.ir
Abstract:   (7482 Views)
Background : Teucrium polium (lamiaceae) is a natural source containing numerous antioxidant compounds and T. polium had advised for treatment of wide range of diseases including gout, inflammation and diabetes. In this Study, inhibitory effect of extracts, the most important antioxidant contents of T. polium and correlation between them had determined.
Materials and Methods : Flowering branches of T. polium were collected from nine regions in north-eastern provinces of Iran and dried and powdered afterwards. The inhibitory effects of the plant extract on xanthine oxidase were assayed in vitro. Total Phenol and anthocyanin and soluble sugar content of each extract were matured. Then, their correlations with the inhibitory effects on xanthine oxidase were also determined. All these measurements were repeated three times and variance analysis was used for comparing means.
Results : All extract in different habitat exhibited a good inhibition effects on xanthine oxidase activity, the concentration of 0.3 mg/ml of samples were inhibited the enzyme from 11.44 to 91.45%. The highest inhibitory effect on xanthine oxidase was found in Ramian by 91.45%. Anthocyanin content in Golestan’s samples (Tilabad) was remarkably more than other samples, 4.26 mg/g DW. Razari khorasan’s samples (Garmab) had the highest of total phenol and soluble sugar contents, 28.11 and 6.84 mg/g DW respectively.
Conclusion : These results suggest that T. polium extract in different regions is a rich source of antioxidant and has inhibitors effect on xanthine oxidase. Golestan samples had the highest inhibitory effect on the xanthine oxidase activity and are recommended for pharmacological studies.
Keywords: Teucrium polium, Xanthine Oxidase Inhibition, Antioxidant, Gout
Full-Text [PDF 143 kb]   (1755 Downloads)    
Type of Study: Research | Subject: Biochemistry
* Corresponding Author Address: Department of Biology, Faculty of Science, Golestan University, Gorgan, Iran
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Saghafi E, Mianabadi M, Hadadchi G. Inhibition Effects of Teucrium Polium Extract on Gout. ZJRMS. 2013; 15 (11) :24-28
URL: http://zjrms.ir/article-1-2339-en.html

Volume 15, Issue 11 (Basic Science Issue - November 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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