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ZJRMS 2013, 15(8): 46-48 Back to browse issues page
Antiviral Effect Assay of Aqueous Extract of Echium Amoenum-L Against HSV-1
Malihe Farahani
, ami.airia@gmail.com
Abstract:   (5887 Views)
Background : Medicinal plants have been used for different diseases in past. There is an increasing need for substances with antiviral activity since the treatment of viral infections with the available antiviral drugs often leads to the problem of viral resistance. Therefore in the present study Echium amoenum L plant with ethnomedical background was screened for antiviral activity against HSV-1 in different times.
Materials and Methods : Flower part of Echium amoenum L plant collected from Iran was extracted with different methods to obtain crude aqueous extract. This extract was screened for its cytotoxicity against Hep II cell line by CPE assay. Antiviral properties of the plant extract were determined by cytopathic effect inhibition assay.
Results : Echium amoenum L extract exhibited significant antiviral activity at non toxic concentrations to the cell line used. Findings indicated that plant extract has the most antiviral activity when it used an hour after virus inoculation.
Conclusion : Echium amoenum L plant had not toxic effect at highest concentrations to the cell lines used and showed the most antiviral activity when it used an hour after virus inoculation. Further research is needed to elucidate the active constituents of this plant which may be useful in the development of new and effective antiviral agents.
Keywords: Antiviral effect, Echium amoenum L, HSV-1
Full-Text [PDF 114 kb]   (1660 Downloads)    
Type of Study: Research | Subject: Virology
* Corresponding Author Address: Department of Microbiology, Qom Branch, Islamic Azad University, Qom, Iran
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Farahani M. Antiviral Effect Assay of Aqueous Extract of Echium Amoenum-L Against HSV-1. ZJRMS. 2013; 15 (8) :46-48
URL: http://zjrms.ir/article-1-2189-en.html


Volume 15, Issue 8 (Basic Science Issue - August 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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