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ZJRMS 2013, 15(6): 50-53 Back to browse issues page
Effect of Hexanic and Alcoholic Extracts of Fenugreek Seed in Male Diabetic Rats
Mahmood Abedinzade , Iraj Nikokar, Sima Nasri, Masome Amal Omidi, Farzad Nursabaghi
, mahmood.abedinzade@gmail.com
Abstract:   (16153 Views)
Background : Diabetes mellitus is recognized with severe complications. Many herbal medicines have been recommended for treatment of diabetes problem. In this study, the effect of hexanic and alcoholic extracts of fenugreek (Trigonella-foenum graecum) on serum parameters was investigated in normal and streptozotocin-induced diabetic rats.
Materials and Methods : This experimental study was carried out in 2011 at paramedical school of Guilan University of Medical Sciences, 48 male Sprague Dawley rats (230-300 gram) were divided into six groups: control, type 1 diabetic, and 2 diabetic groups that receive alcoholic extract and 2 groups receive hexanic extract of fenugreek (100, 200 mg/kg body weight) intraperitonealy for 28 days. For diabetes induction, streptozotocin (60 mg/kg/ intraperitonealy) was used. Blood glucose, total cholesterol, triglyceride (TG), urea, creatinine, uric acid, AST and ALT level was measured. Data were analyzed with spss software 16 and One Way ANOVAs and Tukey test. p<0.05 was statistically significant.
Results : fenugreek extract inhibit weight loss especially in diabetic groups that receive hexanic extract (p=0.006). blood glucose, total cholesterol, TG, urea, creatinin, uric acid, AST and ALT level was reduced significantly in diabetics groups that receive fenugreek extract (p=0.001). This effect was stronger in groups that receive Hexanic extract
Conclusion : Fenugreek is a good candidate for reduction of diabetic complications. 
Keywords: Diabetes Complications, Trigonella, Cholesterol, Blood glucose
Full-Text [PDF 68 kb]   (2127 Downloads)    
Type of Study: Research | Subject: Physiology
* Corresponding Author Address: Department of Physiology, Zeinab Para Medicine-Nursing & Midwifery School, Guilan University of Medical Science, Langrood, Iran
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Abedinzade M, Nikokar I, Nasri S, amal Omidi M, Nursabaghi F. Effect of Hexanic and Alcoholic Extracts of Fenugreek Seed in Male Diabetic Rats . ZJRMS. 2013; 15 (6) :50-53
URL: http://zjrms.ir/article-1-2142-en.html

Volume 15, Issue 6 (Basic Science Issue - June 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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