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:: Volume 15, Issue 4 (Clinical Science Issue - April 2013) ::
ZJRMS 2013, 15(4): 12-16 Back to browse issues page
Comparison of Triple Therapy plus Probiotic Yogurt vs. Standard Triple Therapy on Helicobacter Pylori Eradication
Vahid Mirzaee , Omidreza Hosseini
, vah_mirzaee@yahoo.com
Abstract:   (5271 Views)
Background : Treatment of Helicobacter pylori as a major cause of gastric diseases is of utmost concern. We aimed to assess efficacy of triple therapy (amoxicillin, clarithromycin and pantoprazole) plus probiotic yogurt (PY) on eradication of H. pylori.
Materials and Methods : Total 102 H. pylori positive patients were divided to 3 groups equally and randomly. For treatment of each group amoxicillin, clarithromycin and pantoprazole were used. Group A had additional PY and Group B ordinary low fat yogurt in their regimen as well. These groups were compared regarding treatment success.
Results : Total number of 88 patients finished the treatment course. The most common experienced side effects were dysgeusia in groups A and B (25.8% and 32.3%, respectively), and dysgeusia with diarrhea and abdominal pain (30.8%) in group C. Eradication rate was, respectively, 61.3%, 64.5%  and 71.3% in group A, B and C of which difference was not statistically significant. However, the difference between 3 groups in regard to education level was statistically significant (p=0.005).
Conclusion : PY enriched triple therapy has decreased side effects of antibiotics consumption however, this has no impact on eradication of H. pylori. PY and triple therapy can be used concomitantly to increase the patient tolerance.
Keywords: Helicobacter Pylori, Probiotic yogurt, Triple therapy, Eradication
Full-Text [PDF 271 kb]   (1958 Downloads)    
Type of Study: Research | Subject: Gastroenterology
* Corresponding Author Address: Department of Gastroenterology, Rafsanjan University of Medical Sciences, Rafsanjan, Iran
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Mirzaee V, Hosseini O. Comparison of Triple Therapy plus Probiotic Yogurt vs. Standard Triple Therapy on Helicobacter Pylori Eradication. ZJRMS. 2013; 15 (4) :12-16
URL: http://zjrms.ir/article-1-2073-en.html


Volume 15, Issue 4 (Clinical Science Issue - April 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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