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:: Volume 15, Issue 8 (Basic Science Issue - August 2013) ::
ZJRMS 2013, 15(8): 30-33 Back to browse issues page
Antifungal and Anti-bacterial Synergistic Effects of Mixture of Honey and Herbal Extracts
Kianoush Khosravi-Darani , Ramin Khaksar , Saeideh Esmaeili , Fatemeh Seyed-Reihani , Alaleh Zoghi , Saeede Shahbazizadeh
, kiankh@yahoo.com
Abstract:   (6998 Views)
Background : By increasing resistance of several bacterial and fungal species to many kinds of antibiotics, applications of natural base compounds e.g. honey and medicinal herbs have been more attractive. The aim of present research is evaluation of anti-bacterial and anticandida effects of three kinds of honey of Iran together with alcoholic extract of mint and zataria, as well as extract and starch of ginger on Staphylococcus aureus, Pseudomonas aueoginosa, Escherichia coli and Candida albicans, as pathogens of human body.
Materials and Methods : Minimum inhibitory concentration (MIC) and minimum additive inhibitory concentration (MAIC) were determined by the agar diffusion method by dilution method in Sabouraud agar. By inoculation of 10 μL from suspension and appearance of colorless vesicles, MIC was determined. Growth inhibition was calculated by ANOVA, Mann-Whitney U and t-student tests. All experiments were conducted three times. MIC for three variety of honey on Staphylococcus aureus (32, 30, 29 %v/v), Pseudomonas aeroginosa, (70, 67, 71 % v/v), Escherichia coli (40, 35, 39 % v/v) and Candida albicans (45, 48, 50 % v/v) are reported. While, the MAIC for the growth inhibition of honeys together with extract of mint and zataria, as well as extract and starch of ginger were reduced.
Results : The results show that ginger extract has more significant impact on microorganism growth with respect to others. Pseudomonas aeroginosa was the most susceptible microorganisms to ginger extract. Growth inhibitory effect of ginger extract was more significant than ginger starch.
Conclusion : Addition of herbal extract increases antibacterial and anticandida properties of honey thus letting hope for a honey benefit and would constitute an alternative way against the resistance to bacteria.
Keywords: Synergism, Honey, Ginger, Mint, Zataria, Antibacterial, Anticandida
Full-Text [PDF 126 kb]   (1819 Downloads)    
Type of Study: Research | Subject: Microbiology
* Corresponding Author Address: Department of Food Technology Research, National Nutrition and Food Technology Research Institute, Faculty of Nutrition and Food Technology, Shahid Beheshti University of Medical Science, Tehran, Iran
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Khosravi-Darani K, Khaksar R, Esmaeili S, Seyed-Reihani F, Zoghi A, Shahbazizadeh S. Antifungal and Anti-bacterial Synergistic Effects of Mixture of Honey and Herbal Extracts. ZJRMS. 2013; 15 (8) :30-33
URL: http://zjrms.ir/article-1-2062-en.html


Volume 15, Issue 8 (Basic Science Issue - August 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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