[صفحه اصلی ]   [Archive]  
:: صفحه اصلی ثبت نام جدید و ارسال مقاله کلیه شماره های مجله آخرین شماره مقالات زیر چاپ ::
:: دوره 15، شماره 5 - ( 3-1392 ) ::
جلد 15 شماره 5 صفحات 39-42 برگشت به فهرست نسخه ها
The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
چکیده:   (4585 مشاهده)
Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).
Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.
متن کامل [PDF 157 kb]   (1678 دریافت)    
نوع مطالعه: پژوهشي | موضوع مقاله: فیزیولوژی ورزش
ارسال نظر درباره این مقاله
نام کاربری یا پست الکترونیک شما:

CAPTCHA code


XML   English Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fallah-Mohammadi Z, Ebrahimzadeh M, Hajizadeh-Moghaddam A. The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats . ZJRMS. 2013; 15 (5) :39-42
URL: http://zjrms.ir/article-1-2049-fa.html

The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats . Zahedan Journal of Research in Medical Sciences. 1392; 15 (5) :39-42

URL: http://zjrms.ir/article-1-2049-fa.html



دوره 15، شماره 5 - ( 3-1392 ) برگشت به فهرست نسخه ها
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 32 queries by YEKTAWEB 3897