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ZJRMS 2013, 15(5): 39-42 Back to browse issues page
The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats
Ziya Fallah-Mohammadi , Mojtaba Ebrahimzadeh, Akbar Hajizadeh-Moghaddam
, ziafalm@yahoo.com
Abstract:   (4618 Views)
Background : Amyloid Beta (1-42) is derived from amyloid precursor protein and plays a critical role in AD pathogenesis. The purpose of this study was to investigate the effect of 6 weeks of voluntary wheel running on brain Amyloid beta (1-42) in the diabetic rats induced with alloxan.
Materials and Methods : 28 male rats weight 185±1 were assigned randomly to 4 groups (N=7): normal control (C), training (T), control-diabetic (CD) and diabetic-training (DT). Diabetes was induced with injecting Alloxan (120 mg/kg dissolved in saline) intraperitoneal.
Results : 6 weeks of voluntary wheel running decreased the cortex Aβ1-42 in T and DT groups. Aβ1-42 levels significantly decreased in the T and DT in compare with C and CD (p<0.001), respectively. Also Aβ1-42 levels significantly increased in the CD in compare with C (p<0.001).
Conclusion : voluntary exercise had positive effects on decreasing of Aβ1-42 levels during 6 weeks. Therefore it can be recommended as therapeutic strategy for diabetes.
Keywords: Aβ1-42, Voluntary wheel running, Rats
Full-Text [PDF 157 kb]   (1697 Downloads)    
Type of Study: Research | Subject: Sport Physiology
* Corresponding Author Address: Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Mazandaran, Babolsar, Iran
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Fallah-Mohammadi Z, Ebrahimzadeh M, Hajizadeh-Moghaddam A. The Effect of Six Weeks-Voluntary Wheel Running on Brain Amyloid Beta (1-42) Levels of Diabetic Rats . ZJRMS. 2013; 15 (5) :39-42
URL: http://zjrms.ir/article-1-2049-en.html


Volume 15, Issue 5 (Basic Science Issue - May 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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