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:: Volume 15, Issue 6 (Basic Science Issue - June 2013) ::
ZJRMS 2013, 15(6): 43-49 Back to browse issues page
In Vitro Antibacterial Properties of Aqueous Garlic Extract (AEG) Against Multidrug-Resistant Enterococci
Mohammad Bokaeian , Zakaria Bameri
, bokaeian.m@gmail.com
Abstract:   (7710 Views)
Background : As relatively avirulent enteric bacteria, enterococci usually cause infections in immune-compromised patients. The antimicrobial treatment, however, is quite challenging, since enterococci are intrinsically resistant to many antibiotics. Objective of the present study was to examine the antibacterial activity of aqueous garlic extract on isolates of enterococci.
Materials and Methods : In this descriptive research, a total of 120 enterococcus isolates including 70 multidrug-resistant isolates causing different infections were collected from three hospitals in Zahedan. The susceptibility of isolates to different antibiotics was measured by agar diffusion test and antibacterial activity of garlic extract was measured using disc-diffusion and microbroth dilution methods.
Results : Among 120 enterococcus samples, 95 (79.2%) and 25 (20.8%) isolates were E. faecalis and E. faecium respectively. The highest resistance was observed in erythromycin (95.8%) and the lowest resistance (6.7%) in chloramphenicol, while 88.3% and 65.8% of the isolates were resistant to tetracycline and ampicillin respectively. Moreover, 58% of the isolates were Multi-Drug Resistant (MDR) and showed resistance to at least three antibiotics. Antibacterial activity of AGE was characterized by inhibition zones of 16.8±1.8 mm and Minimum Inhibitory Concentration (MIC) ranged from 4 to 32 mg/ml.
Conclusion : The present study suggests that AGE has a significant anti-enterococcal effect and therefore, supports the use of garlic as an herbal remedy in Zahedan.
Keywords: Garlic, MIC, MDR, Enterococcus
Full-Text [PDF 199 kb]   (2922 Downloads)    
Type of Study: Research | Subject: Microbiology
* Corresponding Author Address: Department of Laboratory Sciences, Faculty of Paramedical Sciences, Research Center for Infectious Diseases and Tropical Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
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Bokaeian M, Bameri Z. In Vitro Antibacterial Properties of Aqueous Garlic Extract (AEG) Against Multidrug-Resistant Enterococci. ZJRMS. 2013; 15 (6) :43-49
URL: http://zjrms.ir/article-1-2002-en.html

Volume 15, Issue 6 (Basic Science Issue - June 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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