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:: دوره 17، شماره 2 - ( 12-1393 ) ::
برگشت به فهرست نشریات جلد 17 شماره 2 صفحات 57-59
Investigation of PSEN1, 2 Hot Spots in Iranian Early-Onset Alzheimer's Disease Patients
چکیده:   (5150 مشاهده)
Background : Alzheimer's disease is a progressive, neurodegenerative disease with both genetic and non genetic causes. Familial Alzheimer's disease can be caused by mutations in the amyloid precursor protein, presenilin 1 and presenilin 2. Early-onset familial Alzheimer's disease (autosomal dominantly inherited) accounts for a small fraction (2-3%) of Alzheimer's disease cases. The aim of this study was investigation of exons 5, 7 in PSEN1 and exons 5, 6 in PSEN2 genes in Iranian patients with early onset Alzheimer disease. These exons were hot spots in different country.
Materials and Methods : In this experimental study 24 patients with early onset Alzheimer disease and 48 healthy subjects as control group were included in this study. After DNAs extraction from whole blood, PCR-sequencing was used to amplify and analyze 4 exons.
Results :
Two known mutations (Glu 120 Lys in exon 3 of two patients and Arg 62 His in exon 5 of one patient) were found.
Conclusion :
According to the above findings, these exons were not hot spot in Iran.
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نوع مطالعه: پژوهشي | موضوع مقاله: ژنتیک وبیو لوژی مولکولی
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Akbari L, Noroozian M, Azadfar P, Shaibaninia S, Assarzadegan F, Houshmand M. Investigation of PSEN1, 2 Hot Spots in Iranian Early-Onset Alzheimer's Disease Patients. ZJRMS. 2015; 17 (2) :57-59
URL: http://zjrms.ir/article-1-1960-fa.html
Investigation of PSEN1, 2 Hot Spots in Iranian Early-Onset Alzheimer's Disease Patients. Zahedan Journal of Research in Medical Sciences. 1393; 17 (2) :57-59

URL: http://zjrms.ir/article-1-1960-fa.html

برگشت به فهرست نشریات دوره 17، شماره 2 - ( 12-1393 )
Zahedan Journal of Research in Medical Sciences
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