:: Volume 17, Issue 2 (Basic Science Issue - February 2015) ::
ZJRMS 2015, 17(2): 37-41 Back to browse issues page
Investigating the Anticonvulsant Effects of Repetitive Transcranial Magnetic Stimulation on Perforant Path Kindling Model in Rats
Ali Yadollahpour, S. Mohammed Firoozabadi , S. Javad Mirnajafizade
Department of Medical Physics, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran , pourmir@modares.ac.ir
Abstract:   (16033 Views)
Background : Almost 20% of epileptics are drug resistant. Studies have shown that low frequency repetitive transcranial magnetic stimulation (rTMS) is with therapeutic effects on epilepsy-affected laboratory models. Anticonvulsant effects of rTMS depend on several parameters among which radiation frequency is the most important one. In this study, the therapeutic impacts of 1 and 2 Hz rTMS on convulsing parameters in epileptic model of electrical kindling stimulation of the perforant path were investigated.
Materials and Methods : In this experimental study 21 rats were randomly divided into three groups, namely ‘1 Hz treatment group’ and ‘2 Hz treatment group’ and ‘kindling group’. The kindling group only received kindling stimulations for seven days. One Hz and 2 Hz frequency treatment groups received maximally 5 min rTMS after termination of kindling stimulation per day for a week. Stimulation and stability electrodes had been placed, in turn, on perforant path and dentate gyrus. For quantifying the duration of the subsequent discharge waves, two-way ANOVA test and Bonferroni post-test were employed. In addition, for quantifying the convulsive behaviors, Kruskal-Wallis and the Mann-Whitney U tests were used.
Results :
The results showed that 1 Hz and 2 Hz frequency rTMS have considerable inhibitory impact on the development of convulsive phases. Anticonvulsive effect was observed from the first day after rTMS was undertaken. In addition, the animals did not show fourth and fifth convulsive stages, and a significant reduction was evident in their recorded peak discharge waves compared with kindle group.
Conclusion :
Low frequency rTMS possesses significant anticonvulsive effects which depend upon sTMS stimulation frequency.
Keywords: Cranial magnetic stimulation, Epilepsy, Path kindling, Dentate gyrus
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Type of Study: Research | Subject: Physiology

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Volume 17, Issue 2 (Basic Science Issue - February 2015) Back to browse issues page