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ZJRMS 2012, 14(3): 13-17 Back to browse issues page
The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis
Tayebeh Sanchooli , Zahra Heidari , Hamidreza Mahmoudzadeh-Sagheb , Mohammad Hashemi , Mohammadayub Rigi-Ladez
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Abstract:   (10332 Views)

Background: Chronic periodontitis is an inflammatory disease that causes rapid destruction of the tissues supporting the teeth. Genetic and environmental factors are involved in its occurrence. It has been suggested that IL-6 promoter gene polymorphism could affect the severity of chronic periodontitis. This study has examined the relationship between IL-6 (-174G/C) gene polymorphism and chronic periodontitis.
Materials and Methods:  In this case-control study, 100 patients with chronic periodontitis and 100 healthy individuals referring to the clinic of Zahedan Dental School were evaluated. Two ml of peripheral blood was taken from these people. After DNA extraction through salting out method, IL-6 gene polymorphism was determined through T-ARMS-PCR technique using specific primers. The data were analyzed by chi-square test and p<0/05was considered significant.
Results: The frequency of genotypes CC, GC, GG was respectively 61%, 35% and 4% in patients and respectively 67%, 31% and 2% in the control group. The frequency of G and C alleles was respectively 78.5% and 21.5% in the patient group, and respectively 82.5% and 17.5% in control group. No statistically significant difference was observed between the two groups in frequency of genotypes and alleles.
Conclusion: This study showed no correlation between IL-6-174 G/C gene polymorphism and chronic periodontitis.

Keywords: Chronic Periodontitis, Polymorphism, IL-6
Full-Text [PDF 181 kb]   (2373 Downloads)    
Type of Study: Research | Subject: Genetics and Molecular Biology
* Corresponding Author Address: Research Center for Infectious Diseases and Tropical Medicine, Boo-Ali Hospital, Zahedan, Iran
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Sanchooli T, Heidari Z, Mahmoudzadeh-Sagheb H, Hashemi M, Rigi-Ladez M. The Relationship between Interleukin-6 -174 G/C Gene Polymorphism and Chronic Periodontitis. ZJRMS. 2012; 14 (3) :13-17
URL: http://zjrms.ir/article-1-1863-en.html

Volume 14, Issue 3 (Basic Science Issue - May 2012) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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