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ZJRMS 2013, 15(6): 1-7 Back to browse issues page
The Study of the Effects of Post Treatment with Rosmarinus Officinalis Aqueous Extract the First 48 Hours after Renal Ischemia/Reperfusion in Rats
Saeed Changizi Ashtiyani , Marzieh Zohrabi , Akbar Hassanpoor , Saeed Hajihashemi , Nasser Hosseini
, ashtiyani@sums.ac.ir
Abstract:   (7622 Views)
Background : Acute renal failure induced by ischemia / reperfusion (I/R) causes excretory functional disorders of nephrons. The purpose of this study is to evaluate the intake of oral rosemary extract (gavage) on hemodynamic changes and tissue damages caused by I/R.
Materials and Methods : This study was conducted on 40 Sprague-Dawley male rats, composed of 4 groups (n=10) including control, sham, I/R+normal saline (I/R+NS) post-treatment and I/R+rosemary (I/R+RO) post-treatment. They were fed with 10 ml/kg of 8% aqueous extract or vehicle as gavages during the first 48 hours after I/R. To induce I/R, both renal artery and vein were blocked for 30 minutes followed by a reperfusion within 48 hours. Then urine and plasma samples were collected and histological study was also conducted after removal of both kidneys. Data were analyzed by SPSS-11.5 software. The one-way analysis of variance (ANOVA) and Duncan test were used for intergroup comparison and p≤ 0.05 was used as the significant level. The Kruskal–Wallis multiple comparison test was also used for doing histological analysis
Results : Comparison of renal function between two groups of (I/R+RO) and (I/R+NS), showed a significant reduction in plasma creatinine (p=0.05), the blood urea nitrogen (p=0.05), absolute excretion of sodium (p=0.001) and an increase in absolute potassium excretion (p=0.01). Results of the histological study also indicated a significant decrease in the vascular congestion, Bowman’s capsule space and oxidative stress in the group (I/R+RO) in comparison with (I/R+NS).
Conclusion : Treatment with rosemary may be effective in the reduction of the functional and histological effects of I/R.
Keywords: Acute renal failure Ischemia/reperfusion, Kidney, Rat, Rosmarinus officinalis
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Type of Study: Research | Subject: Physiology
* Corresponding Author Address: Kidney and Blood Pressure Research Center, Arak University of Medical Sciences, Arak, Iran
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Changizi Ashtiyani S, Zohrabi M, Hassanpoor A, Hajihashemi S, Hosseini N. The Study of the Effects of Post Treatment with Rosmarinus Officinalis Aqueous Extract the First 48 Hours after Renal Ischemia/Reperfusion in Rats. ZJRMS. 2013; 15 (6) :1-7
URL: http://zjrms.ir/article-1-1776-en.html


Volume 15, Issue 6 (Basic Science Issue - June 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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