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:: Volume 16, Issue 11 (Clinical Science Issue - November 2014) ::
ZJRMS 2014, 16(11): 1-4 Back to browse issues page
Serum Level of Resistin in Patients with Hyperthyroidism and Hypothyroidism
Mehdi Hedayati , Sanaz Shabani , Mahsa Farazandeh mehr , Marjan Zarif-Yeganeh , Laleh Hoghooghirad
Cellular and Molecular Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , Hedayati@endocrine.ac.ir
Abstract:   (6665 Views)
Background : Resistin hormone is a polypeptide hormone belonging to the family of hormone-like resistin molecules. Controversial results have been reported between serum level of resistin and thyroid abnormalities, including hypothyroidism and hyperthyroidism. The purpose of this study was to evaluate the serum level of resistin hormone in patients with hypothyroidism and hyperthyroidism and its association with weight and body mass index.
Materials and Methods : In this case-control cross sectional study 48 patients with hypothyroidism, 34 patients with hyperthyroidism, and 82 individuals as control group were considered. BMI, fasting resistin, TSH, and T4 serum levels were measured by enzyme immunoassay methods. Data were compared using t-test, Pearson correlation coefficient, and ANOVA to evaluate correlation between variables. p< 0.05 was considered statistically significant.
Results :
Resistin serum levels in hypothyroidism and hyperthyroidism patients was significantly higher than the control group. There was not any significant correlation between resistin serum levels, BMI, age, and thyroid hormones level. Also in hypothyroidism patients a positive correlation was observed between BMI and TSH level, and a negative correlation between BMI and T4 level.
Conclusion :
The result of this study showed the increase in serum level of resistin in patients with thyroid dysfunction. This correlation was independent of BMI changes in patient. The findings suggest that changing in serum level of resistin may be considered as a criterion for diagnosis of thyroid dysfunction. Although, this hypothesis needs to be more study.
Keywords: Resistin, Hypothyroidism, Hyperthyroidism, Body Mass Index
Full-Text [PDF 63 kb]   (1462 Downloads)    
Type of Study: Research | Subject: Biochemistry
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Hedayati M, Shabani S, Farazandeh mehr M, Zarif-Yeganeh M, Hoghooghirad L. Serum Level of Resistin in Patients with Hyperthyroidism and Hypothyroidism. ZJRMS. 2014; 16 (11) :1-4
URL: http://zjrms.ir/article-1-1732-en.html


Volume 16, Issue 11 (Clinical Science Issue - November 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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