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ZJRMS 2013, 15(1): 19-23 Back to browse issues page
Immunohistochemical Expression of Estrogen and Progesterone Receptors in Epulis Fissuratum
Maryam Seyedmajidi , Shahryar Shafaee , Mohammad Azhdari , Sorayya Khafri , Sepideh Siadati , Mohammad Mehdizadeh
, ms_majidi79@yahoo.com
Abstract:   (7144 Views)
Background : Epulis Fissuratum (Epulis Fissuratum (EF) or Denture Epulis or inflammatory fibrous hyperplasia) is a common hyperplastic tumor-like lesion with reactive nature, related to loose and ill-fitting, full or partial removable dentures and it is more common in women than men. For this reason, hormonal influences may also play role in its creation. The effect of steroid hormones especially sex hormones (Estrogen and progesterone) on oral mucosa is identified in some studies. In the present study, the distribution pattern and presence of estrogen and progesterone receptors in epithelial, stromal, endothelial and inflammatory cells in Epulis Fissuratum was investigated.
Materials and Methods : This cross-sectional study was carried out on 30 samples of paraffin blocks with Epulis Fissuratum diagnosis and 30 samples of normal mucosal tissues as a control group who have had surgery as a margin beside the above lesions and had been obtained from the oral and maxillofacial pathology departement of Babol Dental School since 2003 up to 2010. Intensity of staining and immunoreactivity were evaluated using subjective index and considering the positive control group (breast carcinoma).
Results : Epithelial, stromal, endothelial and inflammatory cells didn’t show reaction with monoclonal antibodies against estrogen and progesterone in none of the samples.
Conclusion : It seems that the hypothesis of the existence of estrogen and progesterone receptors in epulis fissuratum and normal oral mucosa is ruled out. The possibility of direct effect of estrogen and progesterone in occurring of epulis fissuratum is rejected.

Keywords: Estrogen, Progesterone, Receptor, Epulis fissuratum
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Type of Study: Research |
* Corresponding Author Address: Department of Oral & Maxillofacial Pathology, Dental Materials Research Center, Faculty of Dentistry, Babol University of Medical Sciences, Babol, Iran
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Seyedmajidi M, Shafaee S, Azhdari M, Khafri S, Siadati S, Mehdizadeh M. Immunohistochemical Expression of Estrogen and Progesterone Receptors in Epulis Fissuratum. ZJRMS. 2013; 15 (1) :19-23
URL: http://zjrms.ir/article-1-1688-en.html


Volume 15, Issue 1 (Clinical Science Issue - January 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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