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:: Volume 15, Issue 4 (Clinical Science Issue - April 2013) ::
ZJRMS 2013, 15(4): 53-55 Back to browse issues page
Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency
Raheleh Assaei , Hedayat Nazari , Naser Pajouhi , Saleh Zahedi-Asl
, asaee_ra@yahoo.com
Abstract:   (6985 Views)
Background : Drug abuse is associated with numerous complications including hormonal disorders of hypothalamic-pituitary-gonadal axis and spermatogenic disorders. We have compared the hormone concentration of pituitary-gonadal axis and the semen analysis in opioid-dependent and non-opioid-dependent men.
Materials and Methods : In this case-control study, serum concentration of pituitary- gonadal axis hormones and semen analysis in 48 opioid-dependent men as eligible to participate in the study were compared with those in 12 non-dependent men.
Results : Free testosterone concentration in all test groups was significantly less than that in control group. Furthermore, the concentration of Dihydrotestosterone (DHT) and Dehydroepiandrosterone Sulfate (DHEAS) in all test groups except those addicted to heroin was less than in those in control group. Concentrations of LH, FSH, prolactin, SHBG, progesterone and estradiol, normal and abnormal sperm count in test groups were significantly different from control group. However, in all test groups, sperm motility rate was less than control group. No significant relationship was found between the concentration of sex hormones and the status of sperms motility.
Conclusion : Chronic use of opioids will affect testosterone hormone and sperm, and it will cause hypogonadism and impairment of sperm motility.
Keywords: Addiction, Sex Hormones, Semen Analysis
Full-Text [PDF 131 kb]   (1492 Downloads)    
Type of Study: Short Communication | Subject: Endocrinology
* Corresponding Author Address: Department of Physiology, Faculty of Medicine, Lorestan University of Medical Sciences, Khoramabad, Iran
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Assaei R, Nazari H, Pajouhi N, Zahedi-Asl S. Pituitary-Gonadal Axis Hormone and Semen Analysis in Narcotic Dependency . ZJRMS. 2013; 15 (4) :53-55
URL: http://zjrms.ir/article-1-1680-en.html


Volume 15, Issue 4 (Clinical Science Issue - April 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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