[Home ] [Archive]   [ فارسی ]  
:: Main Online Submission Archive Current Issue In Press ::
:: Volume 15, Issue 11 (Basic Science Issue - November 2013) ::
ZJRMS 2013, 15(11): 49-51 Back to browse issues page
Effect of Biebersteinia multifida DC. Root Extract on Cholesterol in Mice
Shahrzad Khakpour , Meisam Akhlaghdoust , Sara Naimi , S. Mohammad-Javad Mirlohi , Media Abedian , Nazilla Sadat Seyed-Forootan , Fatemeh Foroughi
, shahrzad_khakpour@yahoo.com
Abstract:   (5684 Views)
Background : Hypercholesterolemia and atherosclerosis are the most common causes of mortality and disability, especially in developed countries. The aim of this research was to evaluate the effect of Biebersteina multifida DC. root extract on HDL and LDL blood level.
Materials and Methods : In this experimental study, 35 male Balb/c mice were randomly divided in five groups such control, sham, and experimental groups which received Biebersteina multifida DC. root extract with the doses of 4, 5 and 10 mg/kg three last groups were daily fed orally, for thirty days. HDL and LDL blood serum levels were measured, in the last day and compared with control and sham groups.
Results : The results after 30 days gavage of 4, 5 and 10 mg/kg of Biebersteinia Multifida DC. root extract showed that the root extract decrease of LDL level significantly. The doses of 4, 5 mg/kg of the root extract were the effective dose in decreasing the serum HDL level. However, 10 mg/kg dose of root extract has no significant effect on HDL level in comparison with control and sham groups. 10 mg/kg of root extract had the maximum effect on reducing LDL level.
Conclusion : According to this study, it is suggested that the root extract of Biebersteinia multifida DC. can be efficient to reduce the level of HDL and LDL in blood serum.
Keywords: Bibersteinia multifida DC. HDL, LDL, Mice
Full-Text [PDF 182 kb]   (1509 Downloads)    
Type of Study: Research | Subject: Physiology
* Corresponding Author Address: Department of Physiology, Medical Sciences Research Center, Islamic Azad University, Tehran Medical Branch, Tehran, Iran
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA code


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khakpour S, Akhlaghdoust M, Naimi S, Mirlohi S M, Abedian M, Seyed-Forootan N S et al . Effect of Biebersteinia multifida DC. Root Extract on Cholesterol in Mice. ZJRMS. 2013; 15 (11) :49-51
URL: http://zjrms.ir/article-1-1601-en.html


Volume 15, Issue 11 (Basic Science Issue - November 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3768