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ZJRMS 2005, 7(1): 9-15 Back to browse issues page
Outcome of reinitiation of combination anti diabetic oral therapy in insulin treated patients with Type 2 Diabetes Mellitus
Abstract:   (5611 Views)

 
Afkhami-ardekani M., MD*; Jafaryzadeh HR., MD**
 
Background: Before adding metformin to oral anti diabetic drugs, only sulfonylureas were available. When sulfonylureas failed, insulin therapy had to be initiated. For this reason utilization of insulin was more than now. The purpose of this study is evaluation of success in reinitiation of oral therapy in insulin treated patients with type 2 diabetes.
Methods and Materials: This study is an outcome study, we attempted reinitiation of combination oral therapy with metformin and a sulfonylurea in 32 patients who had type 2 diabetes for less than 30 years and had received less than 40U insulin for less than 10 years.
 Results: Of 32 patients, reinitiation of oral therapy was successful in 20 patients and unsuccessful in 12 (P=0.014).  In 13 of 16 patients with less than 10 years diabetes  duration ,  and in 7 of 16 patients with more than 10 years diabetes  duration, reinitiation of oral therapy was successful(P=0.028).In patients who received  10-25 U/day , %76, and in patients who received 26-40 U/day , %46.7, reinitiation of oral therapy was successful (P=0.05).There was not association between reinitiation of oral therapy and age, duration of insulin therapy, dose of insulin and BMI.
Conclusions: This study shows reinitiation of combination oral therapy in insulin treated patients with type 2 diabetes, is most likely to be successful with a shorter duration of diabetes and lower insulin requirements.
 
 

 
 
*Diabetic Research Senter, Internal disease Dept, Faculty of Medicine, Yazd University of Medical Sciences and health  services, Yazd, Iran.
** Internist.
Keywords: Diabetes Type II, Glybenclamid, Metformin, Combination Therapy
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Outcome of reinitiation of combination anti diabetic oral therapy in insulin treated patients with Type 2 Diabetes Mellitus. ZJRMS. 2005; 7 (1) :9-15
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Volume 7, Issue 1 (Mar 2005) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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