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ZJRMS 2004, 6(1): 9-15 Back to browse issues page
The impact of Gluconate calcium on hypocalcaemia after blood exchange in hyperbilirubinemic newborns
Abstract:   (7101 Views)
Imani M. MD*, Rafighdoost H. PhD**, Mohammadi M. MSc***  
 
Background: Blood exchange is one of therauputic methods for neonatal hyperbilirubinemia.  But this method has some complications. One of these complications is hypocalcemia. In some studies, for avoiding from this   problem, calcium gluconate injection is recomm ended. But in some studies there was any important difference between calcium treated group and the group without calcium prescription.
Due to lack of documented evidences about prevalence of this complication, this study was conducted to compare the result of using calcium gluconate injection in the   incidence of hypocalcemia and hyper calcemia.
Methods and materials: For this purpose in a randomized controlled clinical trial in      Ali_ Asghar pediatric hospital in Zahedan, 40 hyperbilirubin neonates that were hospitalized for blood exchange came into this   study. These patients were randomized in two groups so that they were adjusted in terms and preterm delivery.  For 22 patients,      1 ml of calcium glucdnate%10 was   injected in   each 100 ml exchanged blood and for 18 patients (control group), calcium injection wasn’t been done.  Calcium serum level was tested before, immediately after and 6 hours after blood exchange in all patients. Data analysis was been done by means of fishers exact test, Chi_ Square and Binomial test.
Results: In calcium treated patients, hypocalcaemia wasn’t being present after blood exchange. But in non _ calcium treated patients hypo calcemia was seen in 4 cases (%22.4) after blood exchange (P < 0.013). All of these 4 cases were preterm. In calcium treated patients hypocalcaemia had a significant increase after exchange especially in term neonates (P < 0.028).
Conclusions: On the base of these results, in preterm neonates, calcium gluconate injection after blood transfusion exchange is recommended. But this procedure isn’t necessary in term newborns because may result in hyper calcemia.
 
KEY WORDS: Hyperbilirubinemia, Neonatal ichter, Blood exchange, Hypocalcaemia, Hypocalcaemia
 
 * Pediatric disease dept, Faculty of Medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.
 ** Anatomical dept, Faculty of Medicine, Zahedan University of Medical Sciences and health services, Zahedan, Iran.
*** Epidemiology and statistic dept, Faculty of Health, Zahedan University of Medical Sciences and health services, Zahedan, Iran.
Keywords: Hyperbilirubinemia, Neonatal ichter, Blood exchange, Hypocalcaemia, Hypocalcaemia
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Type of Study: Research |
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The impact of Gluconate calcium on hypocalcaemia after blood exchange in hyperbilirubinemic newborns . ZJRMS. 2004; 6 (1) :9-15
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Volume 6, Issue 1 (Mar 2004) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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