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:: Volume 15, Issue 8 (Basic Science Issue - August 2013) ::
ZJRMS 2013, 15(8): 26-29 Back to browse issues page
Hypolipidemic and Antiatherogenic Effects of Satureja Khozestanica Essential Oil in Alloxan-Induced Type 1 Diabetic Rats
Hassan Ahmadvand , Majid Tavafi , Gholamreza Shahsavari , Ali Khosrobeigi , Shahrokh Bagheri , Foad Abdolahpour
, hassan_a46@yahoo.Com
Abstract:   (6911 Views)
Background : The prevalence of diabetes is increasing around the world. Oxidative stress is one of the risk factors in diabetes. The purpose of this study is to examine the protective effects of the essential oil of Satureja khuzestanica on the level of serum lipids and atherogenic indices in the male rats with diabetes.
Materials and Methods : This experimental study was conducted on thirty male rats randomly divided into three groups including: 1- control group, 2- rats with untreated diabetes 3- rats with treated diabetes (through orally intake of water containing 500 ppm of the essential oil of Satureja khuzestanica). The second and third groups also developed diabetes through injection of alloxan tetrahydrate (120 mg/kg). After eight weeks of treatment, their blood sample was taken, and then the levels of glucose, lipids and atherogenic indices of the serum were measured.
Results : The levels of glucose, triglyceride, cholesterol, low density lipoprotein (LDL), very low density lipoprotein (VLDL) and atherogenic indices of plasma in treated diabetic group were significantly decreased. The amount of high density lipoprotein (HDL) was significantly increased in the treated group.
Conclusion : The results obtained from this study showed that the essential oil of Satureja khuzestanica has beneficial effects on the level of serum lipids and atherogenic indices of rats with type 1 diabetes.
Keywords: Diabetes, Serum Lipds, Satureja khozestanica, Essential oil
Full-Text [PDF 70 kb]   (1373 Downloads)    
Type of Study: Research | Subject: Biochemistry
* Corresponding Author Address: Department of Biochemistry, Razi Herbal Medicine Research Center, Lorestan University of Medical Sciences, Khoramabad, Iran
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Ahmadvand H, Tavafi M, Shahsavari G, Khosrobeigi A, Bagheri S, Abdolahpour F. Hypolipidemic and Antiatherogenic Effects of Satureja Khozestanica Essential Oil in Alloxan-Induced Type 1 Diabetic Rats. ZJRMS. 2013; 15 (8) :26-29
URL: http://zjrms.ir/article-1-1241-en.html


Volume 15, Issue 8 (Basic Science Issue - August 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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