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:: دوره 15، شماره 11 - ( 9-1392 ) ::
جلد 15 شماره 11 صفحات 9-14 برگشت به فهرست نسخه ها
The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats
چکیده:   (11377 مشاهده)
Background : The use of medicinal plants for lowering glucose level in diabetic patients is of clinical importance. The present study investigated the effect of a 30-day oral administration of aqueous extract of walnut leaf and glibenclamide on blood glucose level in normal and diabetic rats.
Materials and Methods : In this experimental study, 120 male rats (Sprague-Dawley, 150-250 g) were divided into 12 equal groups as following: normal control group, normal group receiving glibenclamide (4 mg/kg), three normal  groups receiving the extract doses of 50, 10, and 150 mg/kg, alloxan-diabetic control group (170 mg/kg), diabetic group receiving glibenclamide (4 mg/kg), and five diabetic groups receiving the extract in doses of 10, 50, 150, 300, and 500 mg/day by oral administration for 30 days. Glucose levels of the fasting rats were measured at 0, 7th, 14th, 21st, and 30th days using glucometer.
Results : Administration of all doses and over 10 mg/kg significantly lowered the blood glucose level in normal rat and diabetic rats, compared with dose and duration-dependent control groups. This effect was higher for doses of 50 and 150 mg/kg in normal rats and for doses of 300 and 500 mg/kg in diabetic rats, similar to glibenclamide (4 mg/kg).
Conclusion : Walnut leaf aqueous extract, depending on dose and duration, has dose and duration dependent declining effect on glucose level in normal rats and antihyperglycemic effect on diabetic rats, with a few side effects. This effect at some doses is greater or equal to that of glibenclamide.
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نوع مطالعه: پژوهشي | موضوع مقاله: فارماکولوژی
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Noureddini M, Rezaee-Joshogani F. The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats . ZJRMS. 2013; 15 (11) :9-14
URL: http://zjrms.ir/article-1-1148-fa.html

The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats . Zahedan Journal of Research in Medical Sciences. 1392; 15 (11) :9-14

URL: http://zjrms.ir/article-1-1148-fa.html



دوره 15، شماره 11 - ( 9-1392 ) برگشت به فهرست نسخه ها
Zahedan Journal of Research in Medical Sciences
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