[Home ] [Archive]   [ فارسی ]  
:: Main Online Submission Archive Current Issue In Press ::
:: Volume 15, Issue 11 (Basic Science Issue - November 2013) ::
ZJRMS 2013, 15(11): 9-14 Back to browse issues page
The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats
Mahdi Noureddini , Fatameh Rezaee-Joshogani
PhD in Physiology, Physiology Research Center, Kashan University of Medical Sciences, Kashan, Iran , mnoureddini@yahoo.com
Abstract:   (10801 Views)
Background : The use of medicinal plants for lowering glucose level in diabetic patients is of clinical importance. The present study investigated the effect of a 30-day oral administration of aqueous extract of walnut leaf and glibenclamide on blood glucose level in normal and diabetic rats.
Materials and Methods : In this experimental study, 120 male rats (Sprague-Dawley, 150-250 g) were divided into 12 equal groups as following: normal control group, normal group receiving glibenclamide (4 mg/kg), three normal  groups receiving the extract doses of 50, 10, and 150 mg/kg, alloxan-diabetic control group (170 mg/kg), diabetic group receiving glibenclamide (4 mg/kg), and five diabetic groups receiving the extract in doses of 10, 50, 150, 300, and 500 mg/day by oral administration for 30 days. Glucose levels of the fasting rats were measured at 0, 7th, 14th, 21st, and 30th days using glucometer.
Results : Administration of all doses and over 10 mg/kg significantly lowered the blood glucose level in normal rat and diabetic rats, compared with dose and duration-dependent control groups. This effect was higher for doses of 50 and 150 mg/kg in normal rats and for doses of 300 and 500 mg/kg in diabetic rats, similar to glibenclamide (4 mg/kg).
Conclusion : Walnut leaf aqueous extract, depending on dose and duration, has dose and duration dependent declining effect on glucose level in normal rats and antihyperglycemic effect on diabetic rats, with a few side effects. This effect at some doses is greater or equal to that of glibenclamide.
Keywords: Diabetes mellitus, Walnut leaf extract, Glucose, Rat, Glibenclamide
Full-Text [PDF 134 kb]   (1664 Downloads)    
Type of Study: Research | Subject: Pharmacology
Send email to the article author

Add your comments about this article
Your username or Email:

Write the security code in the box >


XML     Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Noureddini M, Rezaee-Joshogani F. The Comparative Effects of Aqueous Extract of Walnut (Juglans regia) Leaf and Glibenclamide on Serum Glucose Levels of Alloxan-Induced Diabetic Rats . ZJRMS. 2013; 15 (11) :9-14
URL: http://zjrms.ir/article-1-1148-en.html


Volume 15, Issue 11 (Basic Science Issue - November 2013) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
Persian site map - English site map - Created in 0.05 seconds with 31 queries by YEKTAWEB 3638