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ZJRMS 2006, 8(1): 9-15 Back to browse issues page
Effect of infusion extract prepared from red nutshell of Pistachio on morphine withdrawal syndrome in rat
Abstract:   (6809 Views)
Background: Many kinds of the plant species can decrease naloxone-precipitated withdrawal
syndrome in experimental morphine-dependent models. In this study, we tried to examine the effect
of infusion obtained from red nutshell of pistachio (Pistacia vera) on withdrawal signs after
administration of naloxone in morphine-dependent male rats.
Methods and Materials: A total of 42 male NMRI rats were used in this study. Animals were
made dependent by chronic administration of morphine during 14 days in their drinking water.
Naloxone (2 mg/kg) was injected intraperitoneally (i.p.) to rats in order to produce behavioral
parameters of withdrawal syndrome for 20 min including diarrhea, writhing and ejaculation.
Weight loss was noticed 24 h after administration of naloxone. In control group (n=10), only
naloxone was injected after dependency in 15th day. While, in other groups (n=8), morphine-treated
rats have been received an infusion of nutshell of pistachio (25, 50, 100 and 200 mg/kg; i.p.), 30
min before naloxone administration.
Results: There were some withdrawal signs such as diarrhea, writhing and weight loss in all
dependent rats after administration of naloxone. The number of writhing in infusion pretreated rats
[25 (P<0.05), 50 (P<0.05) and 100 mg/kg (P<0.01) groups] significantly decreased in comparison
with control group. Diarrhea in all infusion pretreated groups (P<0.01) and weight loss in 50
(P<0.05) and 100 mg/kg (P<0.01) infusion pretreated groups decreased significantly. The most
dramatic decrease in morphine withdrawal signs has been seen in 100 mg/kg infusion pretreated
rats (P<0.01).
Conclusions: The results indicate that an infusion of the red nutshell of pistachio (Pistacia Vera)
can be effective (dose-dependently) on morphine withdrawal syndrome. However, high dose of this
infusion has a toxic effect and future studies should be about mechanisms, pharmacokinetic and
pharmacodynamic properties of the red nutshell infusion of pistachio.
Keywords: KEY WORDS: Pistacia Vera, Withdrawal syndrome, Morphine, Naloxone, Rat *
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Effect of infusion extract prepared from red nutshell of Pistachio on morphine withdrawal syndrome in rat. ZJRMS. 2006; 8 (1) :9-15
URL: http://zjrms.ir/article-1-53-en.html

Volume 8, Issue 1 (Mar 2006) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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