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:: Volume 16, Issue 12 (Basic Science Issue - December 2014) ::
ZJRMS 2014, 16(12): 65-69 Back to browse issues page
Differential Effect of Swimming Stress and Exercise Models in Pentylenetetrazol Induced Kindling of Rats
Hasan Abiri, Mahmoud Elahdadi-Salmani , Shahram Sharafi, Peyman Pajand, Iran Goudarzi, Kataneh Abrari
School of Biology, Damghan University, Damghan, Iran , elahdadi@du.ac.ir
Abstract:   (3695 Views)
Background : Epilepsy is a neurological disorder which is modulated by different situations and activities. Stress and exercise can have effects on epilepsy it can reduce or increase its occurrence. We investigated the effect of acute and chronic stress and also regular moderate exercise on the epileptogenesis.
Materials and Methods : In this experimental study, 82 male Wistar rats divided into 7 groups including 2 exercised and stressed categories, received 40 mg/kg pentylenetetrazol (PTZ) every 48 h up to 13 injections. Then the convulsive behavior was rated by Racine scale. The acute stress was applied by a 30 min swimming session in the water with temperatures of 20, 25 and 32ºC. The chronic stress was created by repeated sessions of 30 min daily swimming for 5 days in 20ºC water. The exercise was a 60 min swimming daily, 5 days a week and for 8 weeks in 25 and 32ºC.
Results : We demonstrated that the acute stress showed a decrease in kindling threshold, except for the stress in 25ºC water which lowered the kindling rate. Similarly, the chronic stress decreased the kindling threshold in the first 5 injections. The exercise did not reduce the kindling threshold but did reduce the kindling rate in both 25 and 32ºC water.
Conclusion : It is concluded that the swimming stress enhanced the kindling process, but the swimming exercise prevented the kindling. Therefore, the animal learns to cope with the condition in a repeated regular physical activity.

Keywords: Kindling, Seizure, Pentylenetetrazol, Exercise, Stress, Wistar rat
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Type of Study: Research | Subject: Physiology
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Abiri H, Elahdadi-Salmani M, Sharafi S, Pajand P, Goudarzi I, Abrari K. Differential Effect of Swimming Stress and Exercise Models in Pentylenetetrazol Induced Kindling of Rats. ZJRMS. 2014; 16 (12) :65-69
URL: http://zjrms.ir/article-1-3096-en.html

Volume 16, Issue 12 (Basic Science Issue - December 2014) Back to browse issues page
Zahedan Journal of Research in Medical Sciences
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